Engineered Immune Cells Offer Promise

Engineered Immune Cells Offer Promise

Engineered Immune Cells Offer Promise


By D. S. Mitchell


Sending Signals

Scientists have genetically engineered immune cells cable of delivering anticancer-signals to organs where cancer may spread. Immunotherapy is a pillar of cancer treatment; strengthening the patient’s immune system and then directing the bolstered immune system to attack tumors. In this effort, Adoptive Cell Transfer is proving successful. With this immunotherapy treatment a patient’s immune cells are collected, engineered for the patient’s specific cancer and then reintroduced into the patient to treat their cancer. There are numerous types of Adoptive Cell Transfer and the most prominent one is called CAR T Cell Therapy.

Cancer Fighting Immune Cells

In 2010 two blood cancer patients received an experimental immunotherapy, and their disease went into remission. The cancer fighting immune cells used in the treatment were still circulating in their bodies,  ten years after the experimental dosing. It indicates that the treatment can be long lasting. Doug Olsen, a native Californian, was one of the patients, “From a patient’s viewpoint, when you are told you are pretty much out of options, the important thing is always to maintain hope. And certainly, I hoped this was going to work”, said Doug Olsen at a news briefing. The CAR T Cell Therapy used the patients’ genetically engineered immune cells to track down and destroy cells that cause cancer.

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Dr. Jill Biden: A Worthy And Empowering Woman

Dr. Jill Biden:
A Worthy And Empowering Woman

By Anna Hessel

Visible Courage

Dr. Jill Biden, is a classic blonde beauty, who served admirably as Second Lady of The United States from 2009-2017, during the historic Obama-Biden administration.  She has, from the beginning of Joe Biden’s presidential campaign, proved a standout surrogate for her husband. She has guts. On Super Tuesday, Jill displayed that courage when protesters charged the stage during  Joe’s speech. Like a star fullback Jill shielded her other half in the midst of the fracas.

Jill-of-All-Trades And Master Of Many

Dr. Jill Biden was the only Second Lady to have a job during her husbands tenure as Vice President.

Dr. Jill Biden was the only Second Lady that ever held a job during her husband’s tenure as Vice President.

This faithful and spirited lady, while being friendly and feminine, has a backbone of pure steel.  Like many of our finest First Ladies, Dr. Jill Biden is an accomplished woman in her own right.  She has been married to the presumptive Democratic presidential nominee, since 1977. While Second Lady she held a paying job (outside of government). Jill Biden is believed to be the only Second Lady to have ever worked during a spouse’s tenure as Vice President of the United States.

Education Her Passion

Jill Biden is a proud wife, mom, grandmother, pet owner and lifelong educator.  She holds a bachelor’s degree from the University of Delaware. She has two masters degrees, the first from Villanova University and the second from West Chester University. And, impressively, a doctoral degree from her first alma mater, U. of Delaware. Dr. Biden has worked diligently to raise awareness of issues important to women, such as preventing breast cancer, the importance of community colleges, and the sacrifices our military families make for America’s future.

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The Dangers Of Sugar

The Dangers Of Sugar

The dangers of sugar are not obvious. The danger comes with the amount and daily intake

The dangers of sugar are compounded by repeated use. Sugar works slowly, its devastating results often taking years to manifest themselves in measurable ways, such as diabetes.

The Dangers Of Sugar

By D. S. Mitchell

When I started writing this article, my intention was to write a quick easy read, nothing in-depth, certainly nothing scientific. Something along the lines of, “Ten Reasons To Kick The Sugar Habit”. That plan was quickly dashed as I read one scary article after another explaining the dangers of sugar consumption. If you are suffering from any of the diseases highlighted in this article, remember, you are not alone. If you want a better, longer life, it is time to take a look at your relationship with sugar in all of its malevolent forms. 


Sixty-Five Pounds Annually

The average American consumes 65 pounds of sugar annually without even being aware of it. That information alone should be a heart stopper. The American Heart Association recommends that men consume no more than 9 teaspoons (36 grams) of added sugar per day and women no more than 6 teaspoons (24 grams). On average each of us ingests 19.5 teaspoons or 78 grams a day. Research on the dangers of sugar on health are ongoing, and new information is being constantly being uncovered.

Dangerous And Addictive

If there was ever any doubt about the dangers of sugar they are being put to rest by a series of scientific studies. Research is proving sugar is both dangerous and extremely addictive. A person who drinks one 20 oz sugary beverage every day will cut their life expectancy by nearly five years. That is,  comparable to being a regular smoker. If that fact doesn’t get your attention, read on, it gets worse, a whole lot worse.

Just As Bad

Sugar does a lot of damage to our bodies.  With all the negative news about sugar is there an alternative?  Some people say, “just use a sugar replacement.” Whoa.  Evidence is mounting that sucralose, saccharin and aspartame are just as dangerous as sugar.  Research shows that sugar replacements injure and destroy the essential microbiome in the gut.  Microbiome are the millions of microorganisms inside our bodies that help us stay alive.  These microbes protect us against germs, they also break down food to release energy, and produce vitamins.

Find A Garbage Can

To make it clear, sugar substitutes are just as bad as the real thing.  In addition to the physical damage products like sucralose do, they are also associated with weight gain and glucose intolerence-the very things people use them to prevent.  Those folks trying to cut down on sugar may be drawn to advertised benefits such as “maple syrup’s antioxidant benefits” or “honey’s healing power”.  Forget such misinformation.  Sugar is sugar, no matter what form it takes. I suggest that no one consume them.  Keep them out of the house.  If you have any of these sugar substitutes in your cupboard toss them in the closest garbage can.

Highs And Lows

The body’s reaction to sugar is like taking a roller coaster ride; an unending ride to extreme highs, followed by extreme lows, sending the body into a spiral of endless cravings. People report being “hungry all the time”. Descriptions include “being obsessed with food”, and literally feeling “addicted” to food. It makes perfect sense, because everything they eat and drink is loaded with sugar.

Addictive Cycle

High sugar intake sends the body into a crazy, roller coaster ride of ups and downs.

The danger of sugar is easy to describe, it is addictive, sharing all the highs and lows of  any other addictive drug.

The danger of sugar is easy to describe.  As the addictive cycle begins, say after you eat a piece of cake, a predictable pattern begins.  Blood glucose begins to rise.  Then, Dopamine, a neurotransmitter that helps control the brain’s reward and pleasure centers is released, messaging that everything is “great”.  Meanwhile, if you are not a diabetic, your pancreas is busy releasing insulin into your blood stream to help lower the threat of rising blood sugar.  High insulin levels signal the body to store fat throughout the body, including the liver.  With the release of insulin, blood glucose drops.

Another Piece Of Cake

As the sugar high subsides, your brain begins sending signals that you are ‘hungry’.  The ‘false hunger’ signals kick cravings into high gear, demanding another piece of cake. Predictably, as you consume that second piece or cake, or cookie, the sugar driven roller coaster takes the body on another crazy, dizzying ride.

Mood Swings

The ups and downs of unstable blood sugar will cause a person to experience mood swings, fatigue, and headaches.  As described in the “addictive cycle” unstable blood glucose contributes to cravings, which begins the cycle of “false hunger”.  When the body is under stress, it immediately kicks into fight-or-flight mode, releasing large amounts of stimulating hormones.  Interestingly, the body has the same chemical response when it detects low blood sugar, created by the insulin response.  After eating a sweet snack, stress hormones begin to compensate for the crash, by raising your blood sugar.  Unexplained anxiousness, irritability, and even tremors often result.  By contrast, those who avoid sugar have fewer cravings, and feel emotionally balanced and energized.


Can’t sleep?  Thirty percent of Americans complain of insomnia, or interrupted sleep.  Sugar may be keeping you up at night.  Researchers have found that eating more sugar, along with less fiber and more saturated fat, is associated with lighter, more disrupted and less restorative sleep.  Insomnia has been connected to diabetes, obesity and heart disease.  This deadly trio of health conditions, is now being directly tied to sugar consumption.

Sugar And Mental Health

Consuming high-sugar products like cookies, candy and sugary drinks, are associated with a higher risk of depression.  Researchers believe that blood sugar swings, neurotransmitter dysfunction, and inflammation may all be reasons for sugar’s detrimental impact on mental health.  Sugar in fact, could be making you sad and depressed.  Capping off a bad day with a comforting sugar laden snack may make you feel worse in the long run.

Increased Depression

A recent Columbia University study found that post-menopausal women whose diets were high in added sugar and refined grains were at a high risk for depression. Study participants, that ate more dietary fiber, whole grains, vegetables, and unprocessed fruits had a decreased risk of depression. In another study, men who consumed 67 grams or more of sugar per day were 23% more likely to develop depression than men who ate less than 40 grams per day.

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