Category: Disease

Patient Gets Genetically Modified Pig Heart

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57 Year Old Gets Genetically Modified Pig Heart

57 year old American man gets genetically engineered pig heart in historic surgery.

57 Year Old Gets Genetically Modified Pig Heart

“It was either die or do this transplant. I want to live. I know it is a shot in the dark, but it is my last chance,” said the recipient of a genetically modified pig heart last week. 

By MAHINROOP PM and D. S. Mitchell

 

A Major Breakthrough 

American doctors have successfully transplanted a genetically modified pig heart into a desperately ill 57 year old patient. It is an unquestionable achievement, a breakthrough for medical science. The patient, David Bennet is doing well after the surgery. The organ transplant proved that a genetically modified animal heart can serve like a human heart without immediate rejection by the body. Bennet had been connected to Extracorporeal Membrane Oxygenation, a heart lung bypass machine, in order to remain alive. The patient was informed of the procedure’s risks and that the procedure was experimental with unknown risks before consenting to receive the heart transplant.

Emergency 

Because Bennet faced certain death without the Food and Drug Administration granted an emergency authorization for the surgery last week. The doctors at University of Maryland Medicine performed the procedure called Xenotransplantation.  Bennet had been on cardiac support for almost two months and couldn’t receive a mechanical heart pump because of an irregular heart beat. Neither could he receive a human transplant, because he had a history of treatment noncompliance.

Organ Shortage Crisis

“This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis. There are simply not enough human hearts available to meet the long list of potential recipients. We are proceeding cautiously, but we are also optimistic that this first in the world surgery will provide an important new option for patients in the future,” said Bartley P Griffith, Professor in transplant surgery at University of Maryland Medicine.

High Risk 

Although the process can potentially save thousands of lives, it comes with many risks including the chance of triggering a dangerous immune response. Such responses can trigger an immediate rejection of the organ, leading to the immediate death of the patient. A  new drug was combined with conventional anti-rejection drugs to suppress the immune system and hopefully will prevent Benet’s body from rejecting the foreign organ.

Ethical and Technical Hurdles

Doctors will monitor Bennet for the rest of his life to determine whether the transplant provides the hoped for lifesaving benefits vs complications. The ultimate focus of xenotransplantation research is on genetically modified pigs because of the physiologic similarities between pigs, human  and non-human primates. Revivicor, a biotechnology company located in Virginia provided the pig heart for the transplantation.

What The Future Offers

Transplant surgeons are hoping that recent advances will enable them to give more people animal organs. Physicians believe that the surgery will kickstart clinical xenotransplantation. As with everything, there are numerous ethical, as well as regulatory issues confronting the wholesale use of animal harvested hearts, and other organs, to sustain human life. Only time will tell.

The Dangers of Permafrost Thaw

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The Dangers Of Permafrost Thaw

Permafrost thaw is a growing danger

The Dangers of Permafrost Thaw

By Anne Rose Muiruri

What Is Permafrost?

Permafrost is any sort of frozen ground, ranging from soil to sediment to rock, that has remained frozen for at least two years and as long as hundreds of thousands of years. It can range in depth from a few feet to more than a mile beneath the earth’s surface, covering huge regions like the Arctic tundra or a single, isolated point like an alpine permafrost mountaintop.

Microbial Breakdown

Microbes that breakdown the carcasses of plants and animals release carbon dioxide, methane, and other global warming gases into the air. A deep freeze successfully halts that process, preserving organisms as well as the gases they would otherwise release underground in the permafrost. The microbial decomposition of those organic materials—and the emission of greenhouse gases—restarts when frozen soil thaws.

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Looking At Elder Care

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Looking At Elder Care

Caring for an elder family member requires strength, patience, and support.

Looking At Elder Care

The Build Back Better legislation stuck in the Senate would provide relief for many American family members struggling to keep a family member living at home vs being placed in a nursing home.

By D. S. Mitchell

Caregiver Risks

Most of the people called on to help an ill or disabled family member have no training in being a caregiver. Not only that, but many spouses, sisters, brothers, sons and daughters have their own health problems and physical limitations. The risks of being a family caregiver is premature aging, sickness, death, depression, anger, resentment and potential financial loss. Aside from that, it can be rewarding and more worthwhile than anything you will ever do.

Financial Resources Make the Difference

Receiving affordable or free home care may be what makes the difference between a family member being able to stay in their home or being moved into an assisted living or nursing home. One in five Americans provide unpaid care to family members so they can continue to live in their home, according to a recent AARP report.

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“Just Dave” 09/19/2021

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“Just Dave” 09/19/2021

“Just Dave” 09/19/2021

Today, Dave is talking about the unvaccinated. The current epidemic is one of the unvaccinated. How come suddenly people would rather die on the battleground of stupidity than take an incredibly safe deterrent. Nothing is perfect, and that includes vaccines. Yet when tossing the dice the odds of surviving the vaccine far outweigh surviving COVID. How could anyone in their right mind want to take the chance of being paralyzed with drugs, have a tube shoved down their throat, a catheter shoved into your bladder, turned every hour so you don’t get bed sores? Now this isn’t going to be a two hour or two day affair. This could go on for months, until you die, or improve. If you die, most likely your last moments will be alone.  If you are lucky there may be a nurse there to hold your hand as you pass. So unnecessary.

Please, stop the silly nonsense and get vaccinated. Do it for yourself, your community, and the country.

Neanderthal’s Gone, But Not Forgotten

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Neanderthal’s Gone, But Not Forgotten

Homo Sapiens and Neanderthals interbred and we still carry the genes of those ancient ancestors

A 60,000-year-old Neanderthal gene once made us resistant to viruses, but now it may make us vulnerable to it.

 

Neanderthal’s Gone But Not Forgotten

Sonnet Gomes

Half of Neanderthal Genome Survives

Neanderthals died out around 40,000 years ago, but traces of them still remain. In the past decade it has become clear that Neanderthals mated with the ancestors of modern humans, producing viable offspring. Studies indicate that almost half of the Neanderthal genome still survives, scattered in small quantities among most modern people’s DNA. (The exception is those with mostly African ancestors, for Neanderthals seem never to have lived in Africa.)

Two Long Chains

Such genes have been associated with everything from hairiness to fat metabolism. Many seem to be related to the immune system, and to affect the risk of developing diseases including lupus, Crohn’s and diabetes. A pair of recent papers suggest covid-19 belongs on that list as well. Two long sections of DNA, both inherited from Neanderthals, appear to confer resistance or susceptibility to severe covid-19, depending on which is present.

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David Shadrick “Let’s Get Vaccinated”

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David Shadrick “Let’s Get Vaccinated”

David Shadrick “Let’s Get Vaccinated”

Since Joe Biden’s inauguration the federal government has put 100,000,000 COVID-19 vaccines in arms of Americans.  Some people don’t want to get it because Trump has been publicly “anti-vaccer.” But now even this last week the fat orange one told his people to go get the vaccine, after it came out that Melania and Donald got their vaccines, a couple months ago in secret. Well as usual Donald is a day late and a dollar short. Let’s stay focused folks, let’s don’t break ranks now, we are so close to having this Pandemic behind us. Do the patriot thing, wear a mask and get vaccinated, it’s the American thing to do!

https://www.calamitypolitics.com/2019/01/02/value-of-vaccinations/

Guilt By Association

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Guilt By Association

By Trevor K. McNeil

A Little Bit of History Repeating

History is more of a cycle than a straight line. Those who have looked at it closely recognize trends have a tendency to repeat. Themes and progress ebb and flow in the oceans of time. Sadly, there are some areas where the water is darker than others. One such dark spot in the ocean of time is the anti-Chinese sentiment in North America.

An Ill Wind

One of the more damaging aspects of coronavirus, aside from the death toll, is the misinformation being spread about it. One being the Anti-Chinese sentiment, fostered and fueled by President Trump and his surrogates. Attempting to redirect blame from his colossal mismanagement of the pandemic response Trump continues his attacks on China. Our boneheaded and close to illiterate president regularly promotes the idea that the virus “came from China.”

Historical Reference

Did it spread through China first? Yes. Do we know for a fact that it is where the virus originated? Hell no. In fact, the Chinese point an angry finger to the United States military. Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) and coronavirus disease-2019 (COVID-19) is new and poorly understood. The prevailing theory is that the original carrier was a bat. I’m not sure if you’ve ever noticed, but bats fly. Over a fair bit of distance. As a historical reminder the 1918 Spanish Flu pandemic did not originate in Spain, but rather Kansas and was spread by American soldiers.  Not that it matters anyway. The country of origin not nearly as important as how to stop the spread of SARS CoV-2 and cure the disease among those who contract it.

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